Reoviral Updates: 2014 - 2015
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A study investigating potential antiviral treatment against Rotavirus indicated that the bacterial protein flagellin induced a protective effect in mice models. According to the study, flagellin activated the immune system via toll-like receptors and other cellular pathways.
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Researchers investigating Orbiviruses in Brazil sequences and characterized the genomes of 13 Changuinola reoviruses. Their work provided further evidence in favor of reassortment among orbiviruses.
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The controversy over Rotavirus vaccines continues! Researchers performed a prospective study to evaluate the risk of intussusception due to rotavirus vaccination. The researchers found an increase in the risk of intussusception for a monovalent rotavirus vaccine.
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Researchers use reoviral infections in conjuction with photodynamic therapy for treating pancreatic cancer. They found prelimary evidence to suggest that oncolytic reoviral therapy may be a future technique in treating patients with pancreatic cancer.
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Reoviral therapy gained further attention when preliminary, Phase 1 clinical data suggested that oncolytic reoviruses may be useful for treating individuals with gliomas.